IC50: 6.9 nM (PIKfyve)[1]
PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of Inhibited the uptake of lentivirus pseudotyped with the SARS-CoV-2 spike glycoprotein.
[1]. David H Drewry, et al. Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses. J Med Chem