IC50: 0.2 nM (PERK)[1]
PERK-IN-2 is a potent Inhibited PERK autophosphorylation in A459 cells.
[1]. Axten JM , et al. Discovery of 7-metl-5-(1-{[3-(trifluorometl)phenyl]acetyl}-2,3-didro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticul