Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.
Palovarotene suppresses post-traumatic chondrogenesis and osteogenesis and mitigated trauma-induced ectopic bone formation. Palovarotene inhibits subcutaneous and intramuscular heterotopic ossification (HO) in mice. Palovarotene is given orally for 14 days at 1 mg/kg/day starting on post-operative day (POD) 1 or POD-5, and HO amount, wound dehiscence and related processes are monitored for up to 84 days post injury. Compared to vehicle-control animals, Palovarotene significantly decreases HO by 50 to 60% regardless of when the treatment started and if infection is present[1]. Starting from day 1 of injury, half of the Acvr1cR206H/+ mice are treated with Palovarotene by daily gavage for 14 days and the other half received vehicle as control. Analysis by mCT and 3D image reconstruction at day 14 shows that large HO tissue masses have formed in the targeted leg of Acvr1cR206H/+ mutant mice receiving vehicle, but HO formation is greatly diminished in Palovarotene-treated companions by more than 80% based on bone volume/total volume quantification[2].
Reference:
[1]. Pavey GJ, et al. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model. Bone. 2016 Sep;90:159-67.
[2]. Chakkalakal SA, et al. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res. 2016 Sep;31(9):1666-75.
[3]. Lees-Shepard JB, et al. Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity. Elife. 2018 Sep 18;7. pii: e40814.
Palovarotene
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 1mg | ¥338.00 | 现货 | 1 | |
| 5mg | ¥675.00 | 现货 | 1 | |
| 10mg | ¥1,080.00 | 现货 | 1 | |
| 50mg | ¥3,024.00 | 现货 | 1 | |
| 100mg | ¥4,838.00 | 现货 | 1 | |
| 10mM (in 1mL DMSO) | ¥616.00 | 现货 | 1 |
文献被引
本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
产品描述 Description
实验参考方法 Experimental Reference Method
Animal experiment: | Rats[1] A total of 110 young adult pathogen-free male Sprague Dawley rats (Rattus norvegicus; 400-600 g) are used. Rats receive via oral gavage (100 μL) either Palovarotene (1.0 mg/kg) or vehicle as control (5% DMSO in corn oil) prepared every other day for 14 days, starting at postoperative day 1 (POD-1) or POD-5. Rats are euthanized at indicated time points post-injury for ex vivo end point analysis by micro-computed CT (μCT), histology and RT-PCR gene transcript expression. Mice[2] One-month-old Acvr1cR206H/+ mice are provided doxycycline chow for 3 days to induce mutant gene expression globally. Mouse quadriceps muscles are injured by injection with 50 mL of 10mM cardiotoxin. Beginning on the day of injury, Palovarotene or vehicle (1:4 DMSO in corn oil) is administered daily for 14 days by oral gavage (100 mg/mouse from days 1 to 3 and 15mg/mouse from days 4 to 14) using a 20-gauge gavage needle. Palovarotene solution in DMSO is stored at -20°C under argon and diluted (1:4) with corn oil for administration. |
References: [1]. Pavey GJ, et al. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model. Bone. 2016 Sep;90:159-67. |
产品文档 Product Documents
化学性质Chemical Properties
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。