GlpBio

Orexin receptor antagonist 2

目录号: GC61770纯度: >98.00%
Orexinreceptorantagonist2是一种有效的增食欲素受体(orexinreceptor)拮抗剂，pKi分别为7.69和9.78。Orexinreceptorantagonist2在失眠症研究中具有潜力。
Orexin receptor antagonist 2
Cas No.: 1457940-75-8
规格价格库存数量操作
5 mg¥4,500.00现货
1
10 mg¥7,650.00现货
1
25 mg¥16,200.00现货
1
50 mg¥27,000.00现货
1
10mM (in 1mL DMSO)¥4,950.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Orexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pKis of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia[1].

[1]. Betschart C, et al. Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J Med Chem. 2013;56(19):7590-7607.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1457940-75-8
SMILES
O=C1N(CC2=CNC3=C2C=C(OC)C=C3)CCCC14CCN(C5=NC(C)=CC(C)=N5)CC4
分子式
C25H31N5O2
分子量
433.55 g/mol
溶解性
DMSO: 62.5 mg/mL (144.16 mM; ultrasonic and warming and heat to 60°C)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol