GlpBio

Homocarbonyltopsentin

目录号: GC36250纯度: >98.00%同义词: PK4C9
Homocarbonyltopsentin (PK4C9) 是结合 TSL2 的小分子化合物，高羰基形成蛋白，与 TSL2 的 pentaloop 构象结合并促进向三叶草构象的转变，增强 SMN2 外显子7 (E7) 剪接，EC50 值为 16 μM。
Homocarbonyltopsentin
Cas No.: 172286-77-0
规格价格库存数量操作
100mg¥0.01现货
1
250mg¥0.01现货
1
500mg¥0.01现货
1
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文献被引

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产品描述 Description

Homocarbonyltopsentin (PK4C9) is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing with EC50 value of 16 μM[1].

Homocarbonyltopsentin (PK4C9) (10-40 μM; 24 hours) shows an up to 5.2-fold decrease in the expression of E7-excluding SMN2 isoforms, and up to three-fold increase in E7-including isoforms in GM03813C cells[1].Homocarbonyltopsentin (PK4C9) (40 μM; 24 hours) increased 1.5-fold SMN protein expression compared to GM03813C cells treated with DMSO[1]. RT-PCR[1] Cell Line: GM03813C (SMA) cells; GM03814B fibroblasts cells

[1]. Garcia-Lopez A, et al. Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes. Nat Commun. 2018 May 23;9(1):2032.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
172286-77-0
同义词
PK4C9
SMILES
O=C(C1=NC=C(C(C2=CNC3=C2C=CC=C3)=O)N1)C4=CNC5=C4C=CC(O)=C5
分子式
C21H14N4O3
分子量
370.36 g/mol
溶解性
DMSO: 125 mg/mL (337.51 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol