GlpBio

8-Azaadenosine

目录号: GC50588纯度: >98.50%同义词: NSC 72961
A nucleoside analog and an ADAR1 inhibitor
8-Azaadenosine
Cas No.: 10299-44-2
规格价格库存数量操作
5mg¥900.00现货
1
10mg¥1,350.00现货
1
25mg¥2,970.00现货
1
50mg¥4,455.00现货
1
10mM (in 1mL DMSO)¥990.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro.

Zipeto et al (2016) ADAR1 activation drives leukemia stem cell self-renewal by impairing let-7 biogenesis. Cell Stem Cell 19 177 PMID:27292188 |Zhang and Slack et al (2016) ADARs edit microRNAs to promote leukemic stem cell activity. Cell Stem Cell 19 141 PMID:27494666

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
10299-44-2
同义词
NSC 72961
SMILES
NC1=NC=NC2=C1N=NN2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
分子式
C9H12N6O4
分子量
268.23 g/mol
溶解性
DMSO : 250 mg/mL (932.04 mM; Need ultrasonic); H<sub>2</sub>O : 3.33 mg/mL (12.41 mM; ultrasonic and warming and heat to 60°C)
保存条件
Store at -20&#176;C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol