Olivetolic acid is a natural polyketide compound that serves as the universal biosynthetic precursor of all cannabinoids in Cannabis sativa[1-2].
In a mouse model of Dravet syndrome Scn1a⁺/⁻, a single intraperitoneal injection of 10-100mg/kg of Olivetolic acid, Olivetolic acid (100mg/kg), significantly increased the temperature threshold of heat-induced tonic-clonic seizures by about 0.4°C, showing anticonvulsant effects[3].
References:
[1] Giangrossi M, Salamone S, Camola A, et al. Taglialatela-Scafati O, Chianese G, Gargiulo E, Nabissi M, Pollastro F. Biomimetic synthesis of rare cannabigerol-type cannabinoids and evaluation of their cytotoxic effect on human glioblastoma cell lines. Fitoterapia. 2025 Mar;181:106354.
[2] Ismed F, Farhan A, Bakhtiar A, et al. Crystal structure of olivetolic acid: a natural product from Cetrelia sanguinea (Schaer.). Acta Crystallogr E Crystallogr Commun. 2016 Oct 18;72(Pt 11):1587-1589.
[3] Anderson LL, Udoh M, Everett-Morgan D, et al. Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome. J Cannabis Res. 2022 Jan 4;4(1):2.
Olivetolic acid是一种天然聚酮化合物，为大麻中所有大麻素类物质的生物合成前体，可用于研究植物次生代谢及大麻素合成途径[1-2]。
在Dravet综合征Scn1a⁺/⁻小鼠模型中，单次腹腔注射10-100mg/kg的Olivetolic acid，Olivetolic acid（100mg/kg）可显著提高热诱导强直-阵挛发作的温度阈值约0.4°C，表现出抗惊厥效果[3]。