Calcitonin Gene Related Peptide (CGRP) (83-119), rat is a 37 amino acid calcitonin family of neuropeptide, acts through calcitonin receptor-like receptor (CRLR).
Calcitonin Gene Related Peptide (CGRP) (83-119), rat belongs to the calcitonin family of neuropeptides which also includes adrenomedullin, amylin, calcitonin, intermedin and calcitonin receptor-stimulating peptide. Calcitonin Gene Related Peptide (CGRP) has two isoforms (αCGRP and βCGRP), and acts through calcitonin receptor-like receptor (CRLR)[1]. Calcitonin Gene Related Peptide (CGRP) plays a key role in migraine pathophysiology and is associated with activation of the trigeminovascular system. CGRP prossibly acts postjunctionally in these areas putatively involved in primary headaches[2].
CGRP is a potent inducer of oedema in rat orofacial tissue. CGRP (100 μL; 8-33 pmol) induces a rapidly developing (5-15?min) and long-lasting (6?h), dose-dependent oedema in the rat cheek. CGRP induces a smaller oedematogenic effect in the rat hind paw also blocked by the CGRP antagonist. CGRP (16 pmol) potentiates the oedema induced by co-injected substance P (3.7 nmol)[3].
[1]. S. Ghatta, et al. Calcitonin gene-related peptide: Understanding its role. Educational Forum. 20.6.2004. [2]. Eftekhari S, et al. Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level. BMC Neurosci. 2011 Nov 10;12:112. [3]. Queiroz BFG, et al. Calcitonin-gene related peptide is a potent inducer of oedema in rat orofacial tissue. Neuropeptides. 2018 Apr;68:43-48.