MDK35833 is an inducer of octamer-binding transcription factor 3/4 (Oct3/4) expression.1 It induces Oct3/4 expression in reporter assays using HEK or NCCIT cells when used at a concentration of 10 ?M. MDK35833 (20 ?M) induces expression of the genes encoding the pluripotency-associated proteins NANOG, REX1, and KLF4 in primary human fibroblasts.
1.Cheng, X., Dimou, E., Alborzinia, H., et al.Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and derivatives as potent Oct3/4 inducersJ. Med. Chem.58(12)4976-4983(2015)