GlpBio

NH2-C4-NH-Boc

目录号: GC39114纯度: >98%同义词: N-叔丁氧羰基-1,4-丁二胺
COASDSData Sheet
NH2-C4-NH-Boc (compound 15) 是一种 PROTAC 连接桥，属于 Alkyl/ether 类。NH2-C4-NH-Boc 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过连接桥连接的不同配体；一种是 E3 泛素连接酶配体，另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。
NH2-C4-NH-Boc
Cas No.: 68076-36-8
规格价格库存数量操作
100mg¥315.00现货
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文献被引

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产品描述 Description

NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181.

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
68076-36-8
同义词
N-叔丁氧羰基-1,4-丁二胺
SMILES
NCCCCNC(OC(C)(C)C)=O
分子式
C9H20N2O2
分子量
188.27 g/mol
溶解性
Water: 100 mg/mL (531.15 mM); DMSO: 100 mg/mL (531.15 mM)
保存条件
4°C, protect from light, stored under nitrogen
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol