Neladalkib TFA is the TFA form of Neladalkib . Neladalkib (NVL-655) is a potent ALK inhibitor. Neladalkib shows antitumor activity. Neladalkib has an IC50 of 2.7 nM for Ba/F3 CLIP1-LTK cells.
References:
[1]. Jennifer Anne Green, et al. Methods of treating solid tumor using (19r)-5-chloro-3-etl-16-fluoro-10,19-dimetl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,6.08,12.013,18]pentacosa-1(24),2(6),4,8,11,13,15,17,21(25),22-decaen-22-amine. WO2023196910A1. [2]. Lin JJ, Horan JC, Tangpeerachaikul A, et al. NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations. Cancer Discov.
















