N8-Acetylspermidine is an endogenous polyamine.1,2,3 Urinary levels of N8-acetylspermidine are increased in patients with chronic pancreatitis.1 Blood levels of N8-acetylspermidine are increased in patients with ischemic cardiomyopathy, as well as in patients with Parkinson’s disease.2,3
1.Nissinen, S.I., Venalainen, M., Kumpulainen, P., et al.Discrimination between pancreatic cancer, pancreatitis and healthy controls using urinary polyamine panelCancer Control291-8(2021) 2.Saiki, S., Sasazawa, Y., Fujimaki, M., et al.A metabolic profile of polyamines in parkinson disease: A promising biomarkerAnn. Neurol.86(2)251-263(2019) 3.Nayak, A., Liu, C., Mehta, A., et al.N8-Acetylspermidine: A polyamine biomarker in ischemic cardiomyopathy with reduced ejection fractionJ. Am. Heart Assoc.9(11)e016055(2020)