N-Etlmaleimide-d5 is the deuterium labeled N-Etlmaleimide. N-Etlmaleimide (NEM), a reagent that alkylates free sulfdryl groups, is a cysteine protease inhibitor[1]. N-etlmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Etlmaleimide is also a deubiquitinating enzyme inhibitor[3].
Stable heavy isotopes of drogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].