N-3-hydroxybutyryl-L-Homoserine lactone is an N-acyl-homoserine lactone produced by the bacterium V. splendidus and has been found in sequencing batch biofilm reactors used in wastewater treatment[1][2]. N-3-hydroxybutyryl-L-Homoserine lactone is a signaling molecule that is involved in bacterial quorum sensing (QS)[3]. N-3-hydroxybutyryl-L-Homoserine lactone senses the density of bacterial population, regulates the cellular process, such as bioluminescence, biofilm formation, and exo-enzyme production[4][5]. N-3-hydroxybutyryl-L-homoserine lactone can be used for screening antimicrobial drugs that interfere with quorum sensing and for studying bacterial infection mechanisms[6][7].
References:
[1] Purohit AA, Johansen JA, Hansen H, et al. Presence of acyl-homoserine lactones in 57 members of the Vibrionaceae family. J Appl Microbiol. 2013;115(3):835-847.
[2] Feng Z, Sun Y, Li T, Meng F, Wu G. Operational pattern affects nitritation, microbial community and quorum sensing in nitrifying wastewater treatment systems. Sci Total Environ. 2019;677:456-465.
[3] Ke X, Miller LC, Bassler BL. Determinants governing ligand specificity of the Vibrio harveyi LuxN quorum-sensing receptor. Mol Microbiol. 2015;95(1):127-142.
[4] Rajamani S, Sayre RT. A sensitive fluorescence reporter for monitoring quorum sensing regulated protease production in Vibrio harveyi. J Microbiol Methods. 2011;84(2):189-193.
[5] Yan G, Fu L, Ming H, Chen C, Zhou D. Exploring an Efficient and Eco-Friendly Signaling Molecule and Its Quorum Quenching Ability for Controlling Microcystis Blooms. Environ Sci Technol. 2023;57(44):16929-16939.
[6] Hanzelka BL, Parsek MR, Val DL, Dunlap PV, Cronan JE Jr, Greenberg EP. Acylhomoserine lactone synthase activity of the Vibrio fischeri AinS protein. J Bacteriol. 1999;181(18):5766-5770.
[7] Sharma N, Pandey S, Yadav M, et al. Biomolecular map of albumin identifies signatures of severity and early mortality in acute liver failure. J Hepatol. 2023;79(3):677-691.
N-3-hydroxybutyryl-L-Homoserine lactone是由Vibrio splendidus细菌产生的N-酰基高丝氨酸内酯，已在用于废水处理的序批式生物膜反应器中被检测到[1][2]。N-3-hydroxybutyryl-L-Homoserine lactone是一种参与细菌群体感应（Quorum Sensing，QS）的信号分子[3]。N-3-hydroxybutyryl-L-Homoserine lactone通过感知细菌群体密度，调控细胞过程，比如生物发光、生物膜形成和胞外酶的产生[4][5]。N-3-hydroxybutyryl-L-Homoserine lactone可用于筛选能够干扰群体感应的抗菌药物，还可用于研究细菌感染机制[6][7]。