9-OxoODE-d3

9-OxoODE-d₃ contains three deuterium atoms at the 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of 9-OxoODE by GC- or LC-mass spectrometry. 9-OxoODE results from oxidation of the allylic hydroxyl of either 9(S)- or 9(R)-HODE. Rabbit reticulocyte plasma and mitochondrial membranes contain both 9- and 13-oxoODEs, representing about 2% of the total linoleate residues in the membranes. Most of these oxidized linoleate residues are esterified to membrane lipids.^1,2,3

1.KÜhn, H., Belkner, J., and Wiesner, R.Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranesEur. J. Biochem.191(1)221-227(1990) 2.KÜhn, H., Belkner, J., and Wiesner, R.Metabolism of polyenoic fatty acids by rabbit reticulocytes. Intracellular action of the erythroid lipoxygenase on membrane lipidsBiomedica Biochimica Acta49S25-S30(1990) 3.KÜhn, H., Belkner, J., Wiesner, R., et al.Occurrence of 9- and 13-keto-octadecadienoic acid in biological membranes oxygenated by the reticulocyte lipoxygenaseArchives of Biochemistry and Biophysics279218-224(1990)