Linoleic acid-d4 is intended for use as an internal standard for the quantification of linoleic acid by GC- or LC-MS. Linoleic acid is an essential ω-6 polyunsaturated fatty acid (PUFA).1 It is the most abundant PUFA in a variety of foods, and dietary sources of linoleic acid include vegetable oils, meats, nuts, seeds, and eggs. Linoleic acid (30 μM) increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay.2 Rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin.3
1.Whelan, J., and Fritsche, K.Linoleic acidAdv. Nutr.4(3)311-312(2013) 2.Ruthig, D.J., and Meckling-Gill, K.A.Both (n-3) and (n-6) fatty acids stimulate wound healing in the rat intestinal epithelial cell line, IEC-6J. Nutr.129(10)1791-1798(1999) 3.Cunnane, S.C., and Anderson, M.J.Pure linoleate deficiency in the rat: Influence on growth, accumulation of n-6 polyunsaturates, and [1-14C]linoleate oxidationJ. Lipid Res.38(4)805-812(1997)