Lyciumin A, a cyclic octapeptide, exhibits inhibitory activity on proteases, angiotensin-converting enzyme. Lyciumin A can be used for the research of pertension[1][2].
Lyciumin A inhibits renin activities by 19.4% (40 μg/mL).
[1]. Kersten RD, et, al. Gene-guided discovery and engineering of branched cyclic peptides in plants. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10961-E10969.
[2]. Rubin GM, et, al. Recent advances in the biosynthesis of RiPPs from multicore-containing precursor peptides. J Ind Microbiol Biotechnol. 2020 Oct;47(9-10):659-674.