Lubeluzole (didrochloride) is a neuroprotective agent which blockades neuronal voltage-gated sodium channels. Lubeluzole (didrochloride) also produces both tonic and block of cardiac sodium channels. Lubeluzole (didrochloride) is promising for research of antiarrthmic agents.
References:
[1]. Le Grand B, et al. Study of the interaction of lubeluzole with cardiac sodium channels. J Cardiovasc Pharmacol. 2003 Nov;42(5):581-7.
[2]. Le Grand B, et al. Lubeluzole-induced prolongation of cardiac action potential in rabbit Purkinje fibres. Fundam Clin Pharmacol. 2000 Mar-Apr;14(2):159-62.