LCB 03-0110, a thienopyridine derivative, is a potent pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor. LCB 03-0110 suppresses scar formation by inhibiting fibroblast and macrophage activation.
LCB 03-0110 suppresses the proliferation and migration of primary dermal fibroblasts induced by transforming growth factor β1 and type I collagen[1].
LCB 03-0110 suppresses the accumulation of myofibroblast and macrophage cells in the healing wound and reduced hypertrophic scar formation after wound closing on rabbit ears[1].
References:
[1]. Sun X, et, al. LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J Pharmacol Exp Ther. 2012 Mar;340(3):510-9.