JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively.
JHDM-IN-1 (Compound 1) also inhibits FIH, PHD3, PHD1, PHD2 and LSD1 with IC50s of 22, 31, 54, 83 and 620 μM, respectively[1].JHDM-IN-1 (0-100 μM) does not inhibit KYSE150 cell growth after treatment for 48 h[1].
References:
[1]. Luo X, et al. A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demetlases. J Am Chem Soc. 2011 Jun 22;133(24):9451-6.