JAK-IN-24

JAK-IN-24 is a JAK inhibitor, with IC50s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24 also inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC50 of 86.171 nM. JAK-IN-24 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

JAK-IN-24 (Example 129 ) inhibits JAK with IC₅₀ values of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP respectively^[1].
JAK-IN-24 shows stability in human whole blood with t_1/2 of 267.223 min^[1].
JAK-IN-24 inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC₅₀ of 86.171 nM^[1].

References:
[1]. Atli Thorarensen, et al. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof. Patent. WO2016178110.