Isoprocurcumenol

Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and AKT. Isoprocurcumenol promotes the proliferation of keratinocytes.

Isoprocurcumenol (10 μM, 0-1 h) increases the phosphorylation of ERK and AKT^[3].
Isoprocurcumenol (0-200 μM, 24 or 48 h) induces the proliferation of keratinocytes HaCaT cells^[3].
Isoprocurcumenol (1 μM, 1 h) increases the expression of genes related to cell growth and proliferation, such as c-fos, c-jun, c-myc, and egr-1, through activation of the EGFR signaling pathway^[3].
Isoprocurcumenol induces cell recovery and wound healing^[3].

References:
[1]. Qu Y, et al. Sesquiterpenes from Curcuma comosa. J Nat Med. 2009 Jan;63(1):102-4.
[2]. Anuchapreeda S, et al. Cytotoxicity and inhibition of leukemic cell proliferation by sesquiterpenes from rhizomes of Mah-Lueang (Curcuma cf. viridiflora Roxb.). Bioorg Med Chem Lett. 2018 Feb 1;28(3):410-414.
[3]. Kwon PK, et al. Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation. Int J Mol Sci. 2021 Nov 22;22(22):12579.