Iron dextran

目录号: GC60940纯度: >98.00%同义词: 右旋糖酐铁; Fe dextran

Iron dextran是一种可注射的复合物，由氢氧化铁和低分子质量的右旋糖酐组成。Iron dextran是一种专门用于治疗缺铁性贫血的静脉铁剂。

Cas No.: 9004-66-4

规格	价格	库存	数量	操作
25 mL	¥1,150.00	现货	1

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Nature
641, 529–536 (2025)
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628, 630–638 (2024)
Nature
632, 686–694 (2024)
Nature
618, 1017–1023 (2023)
Nature
610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
Science
388(6745) (2025)
Science
387(6739) (2025)
Science
387(6734) (2025)
Cell Research
35, 97–116 (2025)
Cell Research
34, 683–706 (2024)
Cell Research
33, 273–287 (2023)
Cell Research
33, 546–561 (2023)
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33, 904–922 (2023)
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31, 1291–1307 (2021)

产品描述 Description

Iron dextran is an injectable complex comprising ferric hydroxide and a low-molecular-weight fraction of dextran. Iron dextran is a type of intravenous iron agent specifically used for the treatment of iron deficiency anemia^[1].

In vitro, Iron dextran(1.9–4000μg/ml; 24h) exhibited certain cytotoxicity to HepG2 cells, with a half - inhibitory concentration (IC₅₀) of 1178μg/ml. When used in combination with TQ (thymoquinone), TQ at a specific dose would enhance its toxicity^[2].

In vivo, Iron dextran (200mg/kg/every other day; 1,2,3 or 4 weeks; i.p.) induces iron overload and CTSB/CTSD up-regulation in the liver and spleen of mice^[3]. Iron dextran (0, 1.1, 3.3 and 9.9mg/(100g·bw·d); 4 weeks; i.g.) played an important role in improving iron deficiency anemia, promoting vitamin D metabolism and activation, regulating iron metabolism balance, and promoting growth and development in rats^[4].

References:
[1] Failla S, Nicolas S, Parmar M. Iron Dextran. 2024 Feb 15. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–.
Failla S, Nicolas S, Parmar M. Iron Dextran. 2024 Feb 15. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 32491679.
[2] Ghasemi F, Ghaffari F, Omidifar N, Taheri Azandaryani M, Nili-Ahmadabadi A. Hepatic Response to the Interaction Between Thymoquinone and Iron-Dextran: an In Vitro and In Vivo Study. Biol Trace Elem Res. 2023 Mar;201(3):1358-1367.
[3] Liang M, Chen L, He Q, Mi X, Qu L, Xie J, Song N. Intraperitoneal injection of iron dextran induces peripheral iron overload and mild neurodegeneration in the nigrostriatal system in C57BL/6 mice. Life Sci. 2023 May 1;320:121508.
[4] Qiu F, Li R, Gu S, Zhao Y, Yang L. The effect of iron dextran on vitamin D3 metabolism in SD rats. Nutr Metab (Lond). 2022 Jul 16;19(1):47.

Iron dextran是一种可注射的复合物，由氢氧化铁和低分子质量的右旋糖酐组成。Iron dextran是一种专门用于治疗缺铁性贫血的静脉铁剂^[1]。

在体外，Iron dextran (1.9-4000μg/ml; 24h)对HepG2细胞表现出一定的细胞毒性，半数抑制浓度（IC₅₀）为1178μg/ml。当与TQ（牛蒡子苷）联合使用时，TQ在特定剂量下会增强其毒性^[2]。

在体内，Iron dextran (200mg/kg/隔一天; 1、2、3和4周; 腹腔注射)可诱导小鼠肝脏和脾脏中铁过载以及组织蛋白酶B（CTSB）和D（CTSD）的上调^[3]。Iron dextran (0、1.1、3.3和9.9mg/(100g·bw·d); 4周; 腹腔注射)在改善大鼠缺铁性贫血、促进维生素D代谢和活化、调节铁代谢平衡以及促进生长发育等方面发挥了重要作用^[4]。

实验参考方法 Experimental Reference Method

Cell experiment [1]:
Cell lines	HepG2 cells
Preparation Method	The HepG2 cell line was cultured in 25cm² flasks containing HG-DMEM medium supplemented with 1% penicillin-streptomycin and 10% fetal bovine serum. The cells were maintained in a humidified atmosphere of 5% CO₂ at 37°C. For cytotoxicity experiments, HepG2 cells were seeded at a density of 10,000 viable cells per well in sterile 96-well plates and incubated overnight at 37°C and 5% CO₂. In the first step, the cells were treated with different concentrations of TQ (0.5-300×10³nM) and Iron dextran (1.9-4000µg/ml) for 24 hours, and the cell viability was determined using the MTT method separately. In the next step, HepG2 cells were pretreated with safe doses of TQ (1.8-15×10³nM) before being exposed to various concentrations of Iron dextran. After 24 hours, 0.5mg/ml of MTT reagent was added to each well and incubated for 4 hours. Finally, 100µl of dimethyl sulfoxide (DMSO) was added to each well to dissolve the formazan crystals, and the changes in absorbance were measured at 570nm using a microplate reader.
Reaction Conditions	1.9-4000µg/ml; 24h
Applications	Iron dextran exhibited certain cytotoxicity to HepG2 cells, with a half - inhibitory concentration (IC₅₀) of 1178μg/ml. When used in combination with TQ (thymoquinone), TQ at a specific dose would enhance its toxicity.
Animal experiment [2]:
Animal models	8-week-old male C57BL/6
Preparation Method	Eight-week-old mice were housed in a near pathogen-free environment (temperature 20°C ± 2°C, humidity 50%–60%, 12h light/dark cycle), with four animals per polypropylene cage and food and water provided ad libitum. Mice were intraperitoneally injected with 200mg/kg Iron dextran every other day for 1, 2, 3, or 4 weeks. Control mice were injected with the same amount of saline.
Dosage form	200mg/kg; 1, 2, 3, or 4 weeks; i.p.
Applications	Iron dextran induces iron overload and CTSB/CTSD up-regulation in the liver and spleen of mice.
References: [1] Ghasemi F, Ghaffari F, Omidifar N, Taheri Azandaryani M, Nili-Ahmadabadi A. Hepatic Response to the Interaction Between Thymoquinone and Iron-Dextran: an In Vitro and In Vivo Study. Biol Trace Elem Res. 2023 Mar;201(3):1358-1367. [2] Liang M, Chen L, He Q, Mi X, Qu L, Xie J, Song N. Intraperitoneal injection of iron dextran induces peripheral iron overload and mild neurodegeneration in the nigrostriatal system in C57BL/6 mice. Life Sci. 2023 May 1;320:121508.

产品文档 Product Documents

批次：Purity:>98.00%

化学性质Chemical Properties

CAS 号

9004-66-4

同义词

右旋糖酐铁; Fe dextran

SMILES

[Iron dextran]

溶解性

Iron, ~100 mg/mL in water

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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