GlpBio

Irisolidone

目录号: GC63514纯度: >99.50%同义词: 尼泊尔鸢尾异黄酮
Irisolidone 是葛根花中的主要的异黄酮。Irisolidone 具有较强的保肝活性。Irisolidone 对阴离子通道 VRAC 具有高效阻断作用。
Irisolidone
Cas No.: 2345-17-7
规格价格库存数量操作
1 mg¥1,170.00现货
1
5 mg¥2,655.00现货
1
10 mg¥4,032.00现货
1
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文献被引

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产品描述 Description

Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for volume-regulated anion channels (VRAC) blockade[1][2][3].

Irisolidone shows the high efficacy for Volume-regulated anion channels (VRAC) blockade with an IC50 of 9.8 μM in HEK293 cells[3].Irisolidone can inhibit endothelial cell proliferation[3].

[1]. Kim SY, et al. Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells. Biochem Biophys Res Commun. 2006 May 26;344(1):3-8.
[2]. Zhang G, et al. Pharmacokinetics of irisolidone and its main metabolites in rat plasma determined by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Nov 15;1005:23-9.
[3]. Xue Y, et al. Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation. Pflugers Arch. 2018 Oct;470(10):1473-1483.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
2345-17-7
同义词
尼泊尔鸢尾异黄酮
分子式
C17H14O6
分子量
314.29 g/mol
溶解性
DMSO : 100 mg/mL (318.18 mM; Need ultrasonic)
保存条件
4°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol