GlpBio

IPN-60090 dihydrochloride

目录号: GC60937纯度: >99.00%
IPN-60090dihydrochloride是一种口服有效、选择性的肾脏型谷氨酰胺酶GLS1抑制剂。GLS1是代谢能生产中一种重要的酶。IPN-60090dihydrochloride可以用于GLS1介导的疾病的研究。
IPN-60090 dihydrochloride
Cas No.: 2102101-72-2
规格价格库存数量操作
1mg¥1,170.00现货
1
5mg¥2,880.00现货
1
10mg¥4,410.00现货
1
10mM (in 1mL DMSO)¥3,836.00现货
1
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文献被引

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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

IPN-60090 dihydrochloride is an orally bioavailable and selective inhibitor of GLS1 (the kidney-type glutaminase), an important enzyme for metabolic energy production. IPN-60090 dihydrochloride can be used in the research of GLS1-mediated diseases[1][2].

IPN-60090 dihydrochloride (Example 1) has an IC50 against GLS1 and an EC50 against A549 cell proliferation of <100 nM[2].

[1]. Maria Emilia Di Francesco, et al. Gls1 inhibitors for treating disease. WO2016004404A2. [2]. Philip Jones, et al. Salt forms and polymorphs of (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide. US20170174661A1.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
2102101-72-2
SMILES
O=C(NC)C1=CN(C[C@H](F)CCC2=NN=C(NC(CC3=NC(C)=CC(OC4CC(F)(F)C4)=C3)=O)C=C2)N=N1.[H]Cl.[H]Cl
分子式
C24H29Cl2F3N8O3
分子量
605.44 g/mol
溶解性
DMSO : 170 mg/mL (280.79 mM; Need ultrasonic); Water : 100 mg/mL (165.17 mM; Need ultrasonic)
保存条件
4&#176;C, away from moisture and light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol