Decreased body weight of the mice after 14-day daily injection of d-INS (5 IU/kg) significantly compared with those injected with the same dose of human Insulin or saline.
Induced rapid phosphorylation of protein kinase B (Akt) in the gut L cells of normal mice.
[1]. Liu S, et al. Insulin detemir enhances proglucagon gene expression in the intestinal L cells via stimulating β-catenin and CREB activities. Am J Psiol Endocrinol Metab. 2012 Sep 15;303(6):E740-51.