INCB059872 didrochloride is a potent, orally active, selective and irreversible Lysine-Specific Demetlase 1 (LSD1) inhibitor. INCB059872 didrochloride can be used for the research of myeloid leukemia[1].
INCB059872 (25 nM; 48 小时; 293T 细胞) didrochloride 增加增强子活性和基因表达[1]。
INCB059872 (25 nM; 48 小时; THP-1 细胞) didrochloride 使 THP-1 在一个细胞倍增时间内或大约 3 天内显示出生长缺陷[1]。
INCB059872 (THP-1 细胞) didrochloride 调节 PRO-seq 分析鉴定基因和增强子[1]。
Western Blot Analysis[1]
| Cell Line: | 293T cells |
| Concentration: | 250 nM |
| Incubation Time: | 48 hours |
| Result: | Increased enhancer activity and gene expression. |
INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 天; C57BL/6J 小鼠) didrochloride 使单细胞 RNA-seq 显示骨髓祖细胞群[1]。
| Animal Model: | C57BL/6J mice[1] |
| Dosage: | 10 mg/kg |
| Administration: | p.o.; 0, 4, or 6 days |
| Result: | Single-cell RNA-seq revealed changes in bone marrow progenitor populations. |
[1]. Johnston G, et al. Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia. Gene. 2020;752:144758.