IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC50 value of <0.1 µM.
IK-930 (compound I-32) (10 mg/kg; p.o.) shows good pharmacokinetic parameters with Cmax of 1088 ng/mL, AUC 0-last of 4581 ng*h/mL in BALB/c mice[1].
References:
[1]. Alfredo C. Castro, et al. Tead inhibitors and uses thereof. WO2020243415A2.