IFN-α-IFNAR-IN-1 is an inhibitor of the protein-protein interaction between the cytokine IFN-α and the IFN-α/β receptor (IFNAR; Kd = 4 ?M for binding to IFN-α).1 It inhibits virus-induced increases in the production of IFN-α and IL-12 in bone marrow-derived plasmacytoid dendritic cells (BM-pDCs) infected with modified Vaccinia virus Ankara (MVA) or vesicular stomatitis virus (VSV) when used at a concentration of 18 ?M. IFN-α-IFNAR-IN-1 also reduces increases in IL-12 production induced by stimulation with the toll-like receptor 9 (TLR9) agonist CpG 2216 or the TLR3 agonist poly(I:C) in the same cells.
1.Geppert, T., Bauer, S., Hiss, J.A., et al.Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactionsAgnew. Chem. Int. Ed. Engl.51(1)258-261(2012)