Sunset yellow FCF is an azo dye.1 It displays an absorption maximum of 480 nm.1,2 It reduces LPS-induced proliferation of isolated mouse splenocytes, as well as inhibits proliferation of isolated mouse splenocytes in an allogenic mixed lymphocyte reaction when used at a concentration of 250 ?g/ml.3 Sunset yellow FCF (0.325 mg/kg) induces chromosomal aberrations in somatic and germ cells and morphological abnormalities in sperm in mice, but it is not genotoxic in a micronucleus gut assay in mice when administered at doses up to 2,000 mg/kg.4 Formulations containing sunset yellow FCF have been used as colorants in food and cosmetic preparations.
1.Ghoneim, M.M., El-Desoky, H.S., and Zidan, N.M.Electro-Fenton oxidation of Sunset Yellow FCF azo-dye in aqueous solutionsDesalination274(1-3)22-30(2011) 2.Sabnis, R.W.Handbook of biological dyes and stains: Synthesis and industrial applications(2010) 3.Yadav, A., Kumar, A., Tripathi, A., et al.Sunset yellow FCF, a permitted food dye, alters functional responses of splenocytes at non-cytotoxic doseToxicol. Lett.217(3)197-204(2013) 4.Sayed, H.M., Fouad, D., Ataya, F.S., et al.The modifying effect of selenium and vitamins A, C, and E on the genotoxicity induced by sunset yellow in male miceMutat. Res.744(2)145-153(2012)