GlpBio

Hydrochlorothiazide Impurity C

目录号: GC43872纯度: >90.00%同义词: 氢氯噻嗪杂质C
A potential impurity found in commercial hydrochlorothiazide preparations
Hydrochlorothiazide Impurity C
Cas No.: 402824-96-8
规格价格库存数量操作
1mg¥3,665.00现货
1
5mg¥10,595.00现货
1
500μg¥1,925.00现货
1
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产品描述 Description

Hydrochlorothiazide impurity C is a potential impurity found in commercial hydrochlorothiazide preparations. [1] Hydrochlorothiazide is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter in the distal and collecting duct nephron segments.[2][3][4]

Reference:
[1]. Fang, X., Bibart, R.T., Mayr, S., et al. Purification and identification of an impurity in bulk hydrochlorothiazide. J. Pharm. Sci. 90(11), 1800-1809 (2001).
[2]. Odlind, B., and Lönnerholm, G. Renal tubular secretion and effects of chlorothiazide, hydrochlorothiazide and clopamide: A study in the avian kidney. Acta.Pharmacol.Toxicol (Copenh) 51(3), 187-197 (1982).
[3]. Majid, D.S.A., and Navar, L.G. Blockade of distal nephron sodium transport attenuates pressure natriuresis in dogs. Hypertension 23(6 Pt 2), 1040-1045 (1994).
[4]. Vongpatanasin, W. Hydrochlorothiazide (HCTZ) is not the most useful nor versatile thiazide diuretic. Curr. Opin. Cardiol. 30(4), 361-365 (2015).

产品文档 Product Documents

Purity:>90.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
402824-96-8
同义词
氢氯噻嗪杂质C
化学名
N-[[7-(aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxido-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide
SMILES
O=S1(C2=CC(S(NCN3C(C=C(Cl)C(S(N)(=O)=O)=C4)=C4S(NC3)(=O)=O)(=O)=O)=C(Cl)C=C2NCN1)=O
分子式
C15H16Cl2N6O8S4
分子量
607.5 g/mol
溶解性
Soluble in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol