GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents[1].
GW438014A (10 mg/kg; i.p.; daily, for 7 d) 抑制大鼠和食物剥夺的遗传性肥胖 ob/ob 小鼠的自发和过夜禁食诱导和 NPY 诱导的摄食[1]。
| Animal Model: | obese ob/ob mice[1] |
| Dosage: | 10 mg/kg |
| Administration: | intraperitoneal injection; daily, for 7 d |
| Result: | Decreased the rate of weight gain in both lean and obese rats. |
[1]. Daniels AJ, et, al. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul Pept. 2002 Jun 15;106(1-3):47-54.