GlpBio

GSTO-IN-2

目录号: GC33342纯度: >98.00%
GSTO-IN-2是一种谷胱甘肽S-转移酶(glutathioneS-transferase)抑制剂，对于GSTA2，GSTM1和GSTP1-1的IC50值分别为3.6，16.3，1.4μM。
GSTO-IN-2
Cas No.: 1202710-57-3
规格价格库存数量操作
5mg¥4,909.00现货
1
10mg¥7,586.00现货
1
25mg¥15,619.00现货
1
50mg¥24,544.00现货
1
100mg¥35,254.00现货
1
10mM (in 1mL DMSO)¥6,703.00现货
1
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文献被引

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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.

GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231.[1].

[1]. Chang KH, et al. Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors. Chem Commun (Camb). 2006 Feb 14;(6):629-31.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1202710-57-3
SMILES
C[C@@]1(-;@[C@@]2([H])[C@H](C)CCC(O)=O)-;@[C@](-;@C-;@C-;@2)([H])-;@[C@@](-;@C-;@C-;@[C@@]3([H])-;@[C@@]-;@4(-;@C-;@C-;@[C@@H](OC([C@@H](NC(CC[C@@H](C(O)=O)N)=O)CC(O)=O)=O)-;@C-;@3)C)([H])-;@[C@]4([H])-;@C-;@C-;@1
分子式
C33H52N2O9
分子量
620.77 g/mol
溶解性
Soluble in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol