Glutaurine是从牛甲状旁腺中分离的一种生物活性二肽，可拮抗可的松与甲状腺素。
Cas No.:56488-60-9
Sample solution is provided at 25 µL, 10mM.
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Glutaurine, a bioactive dipeptide isolated from the bovine parathyroid gland, antagonizes cortison and thyroxin [1]. Glutaurine acts as endogenous modulator in excitatory aminoacidergic neurotransmission and affects the concentration of monoamine neurotransmitters in the brain[2]. Glutaurine has been widely used to promote thymic culture growth and promote macrophage activation[3].
In vivo, Glutaurine treatment via daily oral administration at a dose of 2µg/100g for 7 days resulted in a significant reduction of the hepatic and renal tissue uric acid levels in Tetra-B chicks [4]. Oral administration of a daily dose of 2µg/kg of Glutaurine for 4 days resulted in a significant increase in DNA synthesis in the spleen of CFLB mice without affecting mouse body weight[5]. Glutaurine (50μg/rat; p.o.) effectively restored the latency of entry in the 24 test at the dose of 50μg/rat[6]. Glutaurine (3mg/kg; i.p.) dramatically decreased T3 blood levels without significantly raising T4 blood levels[7].
References:
[1] Feuer L, Katalin S. Effect of litoralon, taurine and other taurine derivatives on the heart muscle cell membrane of the locusta migratoria (migratoriodes RF)[J]. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1981, 69(2): 411-414.
[2] Bittner S, Win T, Gupta R. γ-L-glutamyltaurine[J]. Amino Acids, 2005, 28(4): 343-356.
[3] Feuer L, Török O, Csaba G. Effect of glutaurine, a newly discovered parathyroid hormone on rat thymus cultures[J]. Acta Morphologica Academiae Scientiarum Hungaricae, 1978, 26(2): 87-94.
[4] Feuer L, Tóth B L, Bárdos L. Effect of glutaurine (γ-l-glutamyl-taurine) on serum, hepatic, and renal uric acid levels[J]. Biochemical medicine, 1981, 26(3): 326-329.
[5] Antoni F, Feuer L, Hrabák A, et al. The effect of carrageenan and glutaurine on DNA synthesis of spleen cells in CFLB mice[J]. Biochemical medicine, 1979, 22(2): 238-245.
[6] Feuer L, Török O, Csaba G. Effect of glutaurine, a newly discovered parathyroid hormone on rat thymus cultures[J]. Acta Morphologica Academiae Scientiarum Hungaricae, 1978, 26(2): 87-94.
[7] Baskin S, Bartuska D, Thampi N, et al. The effect of glutaurine on thyroid hormones in the rat[J]. Neuropeptides, 1987, 9(1): 45-50.
Glutaurine是从牛甲状旁腺中分离的一种生物活性二肽，可拮抗可的松与甲状腺素[1]。Glutaurine作为兴奋性氨基酸能神经传递的内源性调节剂，能影响大脑中单胺类神经递质的浓度[2]。Glutaurine已广泛应用于促进胸腺组织培养物的生长及巨噬细胞活化[3]。
在体内，每日口服2µg/100g剂量的Glutaurine连续7天，可显著降低Tetra-B雏鸡肝组织和肾组织中的尿酸水平[4]。连续4日每日口服2µg/kg剂量的Glutaurine，能显著促进CFLB小鼠脾脏DNA合成，且不影响小鼠体重[5]。Glutaurine（50μg/大鼠；p.o.）能显著恢复大鼠进入潜伏期的延长[6]。Glutaurine（3mg/kg; i.p.）显著降低T3血水平，而没有显著提高T4血水平[7]。
| Animal experiment [1]: | |
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Animal models |
Tetra-B chicks |
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Preparation Method |
Tetra-B chicks, age 7 weeks, maintained on standard poultry food, were divided into 2 subgroups and treated daily with 2µg/100g of Glutaurine, dissolved in 0.5ml of tap water. The control group received only 0.5ml of tap water. After 1 week of treatment (at 8 weeks of age) the chicks were bled and their serum uric acid levels were determined. After bleeding, the liver and the kidneys were removed, and tissue samples of about 1g were taken for the determination of uric acid level. |
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Dosage form |
2µg/100g/day for 1 week; p.o. |
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Applications |
Glutaurine treatment resulted in a significant reduction of the hepatic and renal tissue uric acid levels. |
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References: |
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| Cas No. | 56488-60-9 | SDF | |
| 别名 | 磺乙谷酰胺,Litoralon | ||
| 分子式 | C7H14N2O6S | 分子量 | 254.26 |
| 溶解度 | Water : 125 mg/mL (491.62 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.933 mL | 19.6649 mL | 39.3298 mL |
| 5 mM | 786.6 μL | 3.933 mL | 7.866 mL |
| 10 mM | 393.3 μL | 1.9665 mL | 3.933 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet