GlpBio

SR 16832

目录号: GC45566纯度: >98.00%
A dual-site covalent antagonist of PPARγ
SR 16832
Cas No.: 2088135-12-8
规格价格库存数量操作
1mg¥554.00现货
1
5mg¥1,463.00现货
1
10mg¥2,649.00现货
1
25mg¥5,914.00现货
1
50mg¥2,534.00现货
1
100mg¥3,940.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

SR 16832 is a dual-site covalent antagonist of peroxisome proliferator-activated receptor γ (PPARγ).1 It inhibits MRL20-induced allosteric activation of PPARγ in a reporter assay using HEK293T cells when used at a concentration of 5 μM. SR 16832 also reduces basal activity of PPARγ and inhibits binding of docosahexaenoic acid to PPARγ in a time-resolved FRET (TR-FRET) assay.

References
1. Brust, R., Lin, H., Fuhrmann, J., et al. Modification of the orthosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor. ACS Chem. Biol. 12(4), 969-978 (2017).

产品文档 Product Documents

Purity:>98.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
2088135-12-8
SMILES
COC1=CC=C2C(C(NC(C3=CC([N+]([O-])=O)=CC=C3Cl)=O)=CC=N2)=C1
分子式
C17H12ClN3O4
分子量
357.7 g/mol
溶解性
DMSO : 250 mg/mL (698.81 mM; Need ultrasonic)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol