GlpBio

Nonapeptide-1 (acetate)

目录号: GC45529纯度: >95.00%同义词: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, MPFRWFKPV-NH2, 153N-6
An MC1R antagonist
Nonapeptide-1 (acetate)
规格价格库存数量操作
50mg¥2,064.00现货
1
100mg¥3,896.00现货
1
250mg¥6,129.00现货
1
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文献被引

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    183(7):1867-1883 (2020)
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产品描述 Description

Nonapeptide-1 is an antagonist of melanocortin receptor 1 (MC1R; Ki = 40 nM in COS-1 cells expressing human receptors).1 It is selective for MC1R over MC3R, MC4R, and MC5R (Kis = 470, 1,340, and 2,400 nM, respectively). Nonapeptide-1 inhibits cAMP accumulation and melanosome dispersion induced by α-melanocyte-stimulating hormone (α-MSH) in melanocytes with IC50 values of 2.5 and 11 nM, respectively.2

References
1. Schi•th, H.B., Muceniece, R., and Wikberg, J.E.S. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31(6), 565-571 (1997).
2. Jayawickreme, C.K., Quillan, J.M., Graminski, G.F., et al. Discovery and structure-function analysis of α-melanocyte-stimulating hormone antagonists. J. Biol. Chem. 269(47), 29846-29854 (1994).

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

同义词
Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, MPFRWFKPV-NH2, 153N-6
SMILES
O=C([C@H](CCCNC(N)=N)NC([C@H](NC([C@@H]1CCCN1C([C@H](CCSC)N)=O)=O)CC2=CC=CC=C2)=O)N[C@H](CC3=CNC4=C3C=CC=C4)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CCCCN)C(N6CCC[C@H]6C(N[C@H](C(N)=O)C(C)C)=O)=O)=O)=O.CC(O)=O
分子式
C61H87N15O9S.XC2H4O2
分子量
1206.5 g/mol
溶解性
PBS (pH 7.2): 10 mg/ml
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol