Histone H3K14Ac/K18Ac/K23Ac/K27Ac (1-30)-GGK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 2-31 of the human histone H3 sequence. It is acetylated at lysine 14, lysine 18, lysine 23, and lysine 27 and biotinylated via a C-terminal GGK linker. Acetylation of H3K14, H3K18, H3K23, or H3K27 is associated with transcriptional activation, and H3K14 acetylation is required for trimethylation of H3K4.1,2,3,4
References
1. Kimura, H. Histone modifications for human epigenome analysis. J. Hum. Genet. 58(7), 439-445 (2013).
2. Keating, S.T., van Diepen, J.A., Risken, N.P., et al. Epigenetics in diabetic nephropathy, immunity and metabolism. Diabetologia 61(1), 6-20 (2018).
3. Nakanishi, S., Sanderson, B.W., Delventhal, K.M., et al. A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat. Struct. Mol. Biol. 15(8), 881-888 (2008).
4. Barber, M.F., Michishita-Kioi, E., Xi, Y., et al. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 487(7405), 114-118 (2012).