Sulfacetamide is a sulfonamide antibiotic that is bacteriostatic against Gram-positive and Gram-negative bacteria. It inhibits dihydropteroate synthase (IC50 = 9.6 ?M), blocking the synthesis of dihydrofolic acid, and also inhibits bacterial 4-aminobenzoic acid , which is required for the synthesis of folic acid.1
1.Prabhu, V., Lui, H., and King, J.Arabidopsis dihydropteroate synthase: general properties and inhibition by reaction product and sulfonamidesPhytochemistry45(1)23-27(1997)