GlpBio

Metarrestin

目录号: GC38201纯度: >99.50%同义词: ML246
Metarrestin (ML246) is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.
Metarrestin
Cas No.: 1443414-10-5
规格价格库存数量操作
1mg¥409.00现货
1
5mg¥900.00现货
1
10mg¥1,440.00现货
1
25mg¥3,024.00现货
1
50mg¥4,838.00现货
1
10mM (in 1mL DMSO)¥940.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

Metarrestin (ML246) is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.

[1] Kevin J Frankowski, et al. Sci Transl Med. 2018 May 16;10(441):eaap8307.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
1443414-10-5
同义词
ML246
SMILES
O[C@H]1CC[C@H](N(C=NC2=C3C(C4=CC=CC=C4)=C(C5=CC=CC=C5)N2CC6=CC=CC=C6)C3=N)CC1
分子式
C31H30N4O
分子量
474.6 g/mol
溶解性
DMSO: 31.25 mg/mL (65.84 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol