Ferristatin II is an inhibitor of iron uptake.1 It inhibits iron uptake (IC50 = ~12 ?M), as well as induces degradation of transferrin receptor protein 1 (TfR1), an effect that can be reversed by the lipid membrane disruptor nystatin, in HeLa cells. In vivo ferristatin II (0.2, 10, and 40 mg/kg) reduces serum iron levels and transferrin saturation in rats. It also suppresses traumatic brain injury-induced lipid peroxidation, neuronal apoptosis, and the number of cortical iron deposits in rats.2
1.Byrne, S.L., Buckett, P.D., Kim, J., et al.Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivoPLoS One8(7)e70199(2013) 2.Cheng, Y., Qu, W., Li, J., et al.Ferristatin II, an iron uptake inhibitor, exerts neuroprotection against traumatic brain injury via suppressing ferroptosisACS Chem. Neurosci.13(5)664-675(2022)