Suberosin is a prenylated coumarin that has been found in C. articulata and has diverse biological activities.1,2,3 It inhibits platelet aggregation induced by arachidonic acid , collagen, platelet-activating factor (PAF), adenosine 5'-diphosphate , or U-46619 in washed isolated rabbit platelets (IC50s = 60, 132, 200, 234, and 200 ?M, respectively).2 Suberosin (50 or 100 ?M) reduces arachidonic acid-induced formation of thromboxane B2 in the same model. It inhibits NF-κB nuclear translocation induced by phytohemagglutinin (PHA) in, as well as PHA-induced proliferation of, human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 100 ?M.3
1.Paudel, S., Kim, Y., Choi, S.M., et al.Identification of suberosin metabolites in human liver microsomes by high-performance liquid chromatography combined with high-resolution quadrupole-orbitrap mass spectrometerJ. Mass Spectrom.56(4)e4623(2021) 2.Teng, C.M., Li, H.L., Wu, T.S., et al.Antiplatelet actions of some coumarin compounds isolated from plant sourcesThromb. Res.66(5)549-557(1992) 3.Chen, Y.-C., Tsai, W.-J., Wu, M.-H., et al.Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-κBBr. J. Pharmacol.150(3)298-312(2007)