(–)-Secoisolariciresinol is a lignan that has been found in flaxseed and has diverse biological activities.1,2,3 It scavenges DPPH radicals (IC50 = 13.7 ?g/ml in a cell-free assay).1 (–)-Secoisolariciresinol (0.1-100 ?M) stimulates IgM production in HB4C5 hybridoma cells.2 It induces estrogen receptor-dependent gene expression in a reporter assay, as well as stimulates proliferation of MCF-7 human breast cancer cells, in a concentration-dependent manner. (–)-Secoisolariciresinol (5.8 mg/kg, p.o.) reduces weight gain and serum adiponectin levels in a mouse model of obesity induced by a high-fat diet (HFD).3
1.Rao, J.M., Tiwari, A.K., Kumar, U.S., et al.(-)-Secoisolariciresinol as an antioxidant obtained from a new natural source namely Stereopermum personatum(2002) 2.Sugahara, T., Yamauchi, S., Nishimoto, S., et al.The structure-activity relationships of flaxseed lignan, secoisolariciresinolInterdisciplinary Studies on Environmental Chemistry263-268(2008) 3.Tominaga, S., Nishi, K., Nishimoto, S., et al.(–)-Secoisolariciresinol attenuates high-fat diet-induced obesity in C57BL/6 miceFood Funct.3(1)76-82(2012)