GlpBio

P110δ-IN-1

目录号: GC36832纯度: >98.50%
ME-401 (P110δ-IN-1, PWT-143) is an oral, potent and selective inhibitor of Phosphatidylinositol 3-Kinase (PI3K) P110δ with IC50 of 0.6 nM in cellular assay.
P110δ-IN-1
Cas No.: 1595129-71-7
规格价格库存数量操作
1mg¥364.00现货
1
5mg¥1,120.00现货
1
10mg¥1,980.00现货
1
25mg¥3,342.00现货
1
50mg¥4,984.00现货
1
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文献被引

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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    35, 97–116 (2025)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

ME-401 (P110δ-IN-1, PWT-143) is an oral, potent and selective inhibitor of Phosphatidylinositol 3-Kinase (PI3K) P110δ with IC50 of 0.6 nM in cellular assay.

ME-401 is an oral, once-daily, selective PI3Kδ inhibitor with an optimized pharmacologic profile that is in clinical development for the treatment of B-cell malignancies. ME-401 can be orally absorbed, distribute to target tissues, enter and accumulate in target cells, and bind to the target with high affinity to exert its mechanism of action.[2]

[1] Ofir Moreno, et al. Clin Ther. 2018 Nov;40(11):1855-1867. [2] Ofir Moreno, Jamie Wood. Target Oncol. 2019 Oct;14(5):603-611.

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
1595129-71-7
SMILES
O=S(C1=NC2=CC=CC=C2N1C3=NC(N4CCOCC4)=NC(NC(C)(C)CC5=CC=CC=C5C6CCN(C)CC6)=N3)(C)=O
分子式
C31H40N8O3S
分子量
604.77 g/mol
溶解性
DMSO: 20.83 mg/mL (34.44 mM); Water: < 0.1 mg/mL (insoluble)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol