Nimustine is a pyrimidine analog and nitrosourea alkylating agent with anticancer activity.1,2,3 It inhibits the growth of U-251MG and EA285 glioma cells when used at a concentration of 10 μg/ml.2 Nimustine (30 mg/kg) increases the median survival time in a Walker 256 carcinoma rat model of metastatic brain tumors.3
1.Heal, J.M., Fox, P.L., and Schein, P.S.A structure-activity study of seven new water soluble nitrosoureasBiochem. Pharmacol.28(8)1301-1306(1978) 2.Yoshida, J., Shibuya, N., Kobayashi, T., et al.Sensitivity to I-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2- chioroethyl)-3-nitrosourea hydrochloride (ACNU) of glioma cells in vivo and in vitroCancer50(3)410-418(1982) 3.Hasegawa, H., Shapiro, W.R., and Posner, J.B.Chemotherapy of experimental metastatic brain tumors in female Wistar ratsCancer Res.39(7 Pt 1)2691-2697(1979)