L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 ?M for iNOS as opposed to 8-38 and 17-92 ?M for eNOS and nNOS, respectively.1,2,3 L-NIL effectively inhibits iNOS both in vitro and in vivo.4,5,3 L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.3,6
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