NO Synthase
NO Synthase(NO合酶)
Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.
NO Synthase 相关产品(73)
- GA11127H-Arg-OH.HClCAS: 1119-34-2纯度: >98.00%
H-Arg-OH.HCl ((S)-(+)-Arginine hydrochloride) 是合成一氧化氮的氮供体，一氧化氮是一种在镰状细胞危机期间缺乏的强效血管扩张剂。
- GA11233L-NAME hydrochlorideCAS: 51298-62-5纯度: >98.00% / >99.50%
NG-硝基-L-精氨酸甲酯 (L-NAME) 已广泛用于抑制不同生物系统中的组成型一氧化氮合酶 (NOS)。
- GC12867L-NIO dihydrochlorideCAS: 159190-44-0
L-NIO dihydrochloride 是一种有效、非选择性和 NADPH 依赖性一氧化氮合酶 (NOS) 抑制剂，对神经元 (nNOS)、内皮细胞 (eNOS) 和诱导型 (iNOS) 的 Kis 分别为 1.7、3.9、3.9 μM 。
- GC16926L-NMMA acetateCAS: 53308-83-1纯度: >99.00% / >98.00%
L-NMMA acetate是一种强效一氧化氮合酶（NOS）抑制剂，IC 50 值为2μM。
- GC30051Methylene Blue (Basic Blue 9)CAS: 61-73-4纯度: >98.00% / >99.00%
Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.
- GC30774Tat-NR2B9cCAS: 500992-11-0纯度: >98.00%
Tat-NR2B9c 旨在通过阻止突触后密度蛋白 95 (PSD-95) 与 N-甲基-D-天冬氨酸 (NMDA) 受体和神经元一氧化氮结合来阻止一氧化氮 (NO) 的产生氧化物合成酶。
- GC31672Tetrahydrobiopterin (Sapropterin)CAS: 17528-72-2纯度: >99.50%
四氢生物蝶呤 (Sapropterin) ((Rac)-Sapropterin) 是芳香族氨基酸羟化酶的辅助因子，也是所有一氧化氮合酶 (NOS) 同种型的必需辅助因子。
- GC34046BendazolCAS: 621-72-7纯度: >99.00%
Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GA10738 | H-Arg-OH | 74-79-3 | >98.00% | |
H-Arg-OH ((S)-(+)-Arginine) 是内皮一氧化氮合酶 (eNOS) 生成 NO 的底物。 | ||||
| GA11127 | H-Arg-OH.HCl | 1119-34-2 | >98.00% | |
H-Arg-OH.HCl ((S)-(+)-Arginine hydrochloride) 是合成一氧化氮的氮供体，一氧化氮是一种在镰状细胞危机期间缺乏的强效血管扩张剂。 | ||||
| GA11233 | L-NAME hydrochloride | 51298-62-5 | >98.00% / >99.50% | |
NG-硝基-L-精氨酸甲酯 (L-NAME) 已广泛用于抑制不同生物系统中的组成型一氧化氮合酶 (NOS)。 | ||||
| GC12867 | L-NIO dihydrochloride | 159190-44-0 | - | |
L-NIO dihydrochloride 是一种有效、非选择性和 NADPH 依赖性一氧化氮合酶 (NOS) 抑制剂，对神经元 (nNOS)、内皮细胞 (eNOS) 和诱导型 (iNOS) 的 Kis 分别为 1.7、3.9、3.9 μM 。 | ||||
| GC13563 | 1400W dihydrochloride | 214358-33-5 | >98.50% | |
A potent, selective iNOS inhibitor | ||||
| GC16200 | L-Biopterin | 22150-76-1 | >99.50% | |
An intermediate for tetrahydro-L-biopterin | ||||
| GC16656 | L-Canavanine sulfate | 2219-31-0 | >97.00% | |
L-Canavanine硫酸盐是诱导型NO合酶的选择性抑制剂。 | ||||
| GC16664 | 2-Iminobiotin | 13395-35-2 | >98.00% | |
A reversible inhibitor of iNOS and nNOS | ||||
| GC16831 | Agmatine sulfate | 2482-00-0 | >98.00% | |
A polyamine metabolite | ||||
| GC16926 | L-NMMA acetate | 53308-83-1 | >99.00% / >98.00% | |
L-NMMA acetate是一种强效一氧化氮合酶（NOS）抑制剂，IC 50 值为2μM。 | ||||
| GC18259 | DETA NONOate | 146724-94-9 | >98.00% | |
A nitric oxide donor | ||||
| GC18864 | Curvularin | 10140-70-2 | >98.00% | |
A fungal macrolactone | ||||
| GC26091 | ZLc002 | 308277-46-5 | - | |
ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. | ||||
| GC30051 | Methylene Blue (Basic Blue 9) | 61-73-4 | >98.00% / >99.00% | |
Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase. | ||||
| GC30323 | Syzalterin | 94451-48-6 | - | |
Syzalterin是NO生成的抑制剂，其IC50值为1.87μg/mL。 | ||||
| GC30774 | Tat-NR2B9c | 500992-11-0 | >98.00% | |
Tat-NR2B9c 旨在通过阻止突触后密度蛋白 95 (PSD-95) 与 N-甲基-D-天冬氨酸 (NMDA) 受体和神经元一氧化氮结合来阻止一氧化氮 (NO) 的产生氧化物合成酶。 | ||||
| GC31243 | S-MTC | 156719-41-4 | - | |
S-MTC是一种选择性的I型一氧化氮合酶(NOS)抑制剂。 | ||||
| GC31391 | Kuwanon A | 62949-77-3 | >99.50% / >98.00% | |
KuwanonA是从桑树(MorusalbaL.)的根皮中分离的的黄酮衍生物，抑制一氧化氮产生的IC50值为10.5μM。 | ||||
| GC31672 | Tetrahydrobiopterin (Sapropterin) | 17528-72-2 | >99.50% | |
四氢生物蝶呤 (Sapropterin) ((Rac)-Sapropterin) 是芳香族氨基酸羟化酶的辅助因子，也是所有一氧化氮合酶 (NOS) 同种型的必需辅助因子。 | ||||
| GC31673 | GW274150 | 210354-22-6 | >98.00% | |
GW274150是一种新型的NADPH依赖性的iNOS抑制剂。 | ||||
| GC32457 | Asymmetric dimethylarginine | 30315-93-6 | >98.00% | |
An endogenous NOS inhibitor | ||||
| GC32486 | AVE-3085 | 450348-85-3 | >99.50% | |
AVE-3085是一种有效的nitricoxidesynthase增强剂，常用于治疗心血管疾病。 | ||||
| GC34046 | Bendazol | 621-72-7 | >99.00% | |
Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α. | ||||
| GC34255 | TP508 | 121341-81-9 | - | |
TP508是由23个氨基酸残基构成的多肽，它代表了人凝血素的第508-530位氨基酸序列，被认为是高亲和性受体与凝血素的结合域。 | ||||