Licoflavone C is a prenylated flavone that has been found in G. ephedroides and has diverse biological activities.1,2,3 It induces estrogen receptor-dependent gene expression in S. cerevisiae expressing human estrogen receptor α (ERα) in a reporter assay when used at a concentration of 0.1 ?M.1 Licoflavone C inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 macrophages (IC50 = 20.4 ?M).2 It is active against E. coli, P. aeruginosa, and various strains of Candida (MICs = 7.81-15.62 ?g/ml) and is cytotoxic to HepG2 cells (IC50 = 9 ?g/ml).3
1.Garritano, S., Pinto, B., Giachi, I., et al.Assessment of estrogenic activity of flavonoids from Mediterranean plants using an in vitro short-term testPhytomedicine12(1-2)143-147(2005) 2.Han, A.-R., Kang, Y.-J., Windono, T., et al.Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide productionJ. Nat. Prod.69(4)719-721(2006) 3.Edziri, H., Mastouri, M., Mahjoub, M.A., et al.Antibacterial, antifungal and cytotoxic activities of two flavonoids from Retama raetam flowersMolecules17(6)7284-7293(2012)