1β-Acetoxypolygodial is a sesquiterpenoid that has been found in T. lanceolata and has antiprotozoal activity.1,2 It is active against T. cruzi amastigotes and trypomastigotes (GI50s = 57.8 and 72 μM, respectively) but not T. cruzi epimastigotes (GI50 = >100 μM).2
|1. Deans, R.M., Gardiner, M.G., Horne, J., et al. Isolation and characterization of 1•β‐acetoxypolygodial from Tasmannia lanceolata. Asian J. Chem. 3(11), 1193-1196 (2014).|2. Turner, D.N., Just, J., Dasari, R., et al. Activity of natural and synthetic polygodial derivatives against Trypanosoma cruzi amastigotes, trypomastigotes and epimastigotes. Nat. Prod. Res. (2019).