Isosinensetin is a polymethoxylated flavone that has been found in C. reticulata and has anticancer and anti-inflammatory activities.1,2,3 It inhibits P-glycoprotein (P-gp; IC50 = 4.2 ?M) and increases the cytotoxicity of paraquat in MDR1-MDCKII cells and paclitaxel in MX-1 breast and paclitaxel-resistant MX-1/T cancer cells.1 Isosinensetin inhibits the proliferation of A549 lung, HL-60 leukemia, MCF-7 breast, and HO-8910 ovarian cancer cells (IC50s = 23.6, 23.8, 15.1, and 12.5 ?M, respectively).2 It prevents decreases in cell viability and inhibits increases in IL-1β, TNF-α, and IL-6 levels and the production of reactive oxygen species (ROS) induced by fine particulate matter less than or equal to 2.5 ?m (PM2.5) in 16HBE bronchial epithelial cells when used at a concentration of 80 ?g/ml.3
1.Bai, J., Zhao, S., Fan, X., et al.Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationshipsToxicol. Appl. Pharmacol.36949-59(2019) 2.Du, Q., and Chen, H.The methoxyflavones in Citrus reticulata Blanco cv. ponkan and their antiproliferative activity against cancer cellsFood Chem.119(2)567-572(2010) 3.Zou, Y., Li, S., Li, X., et al.Isosinensetin alleviates the injury of human bronchial epithelial cells induced by PM2.5Exp. Ther. Med.22(6)1435(2021)