Glycerol phenylbutyrate (GT4P, HPN-100M, Ravicti) is a nitrogen-binding agent and acts as a sigma-2 (σ2) receptor ligand with a pKi of 8.02. Glycerol phenylbutyrate is a prodrug in which phenylbutyrate (PBA) is released from the glycerol backbone by lipases in the gastrointestinal tract.
[1] Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr. [2] Antonio Rescifina, et al.Eur J Pharm Sci. 2017 Aug 30;106:94-101.
















